Skin is an attractive site for drug administration partly because of its easy accessibility\nand favorable properties (e.g., less invasiveness and high patient compliance) over some other\ncommon routes of administration. Despite this, the effciency in transdermal drug delivery has been\nlargely limited by poor skin permeation. To address this problem, this study reports the generation\nof oleic acid-containing vesicles, which can enhance the drug delivery eciency while showing\ngood stability and limited skin disruption. Upon being loaded into a complex gel, along with the\nincorporation of the polymer blending technique, a delivery system exhibiting tunable transdermal\nflux of 2,3,5,40-tetrahydroxystilbene 2-O--B-D-glucoside is reported. Taking the good biocompatibility\nand tunable delivery performance into account, our system warrants further development and\noptimization for future applications in the treatment of skin diseases.
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